Sjogren's Profile Plus (RDL)

TEST: 520196
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CPT: 83516(x2); 86235(x2)
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Test Includes

Anti-Ro (SS-A); Anti-La (SS-B); Anti-Fodrin Abs, IgG and IgA

Expected Turnaround Time

7 - 10 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

For more information, please view the literature below.

Autoimmune Profiles Brochure

Specimen Requirements

Specimen

Serum

Volume

3 mL

Minimum Volume

2 mL (Note: This volume does not allow for repeat testing.)

Container

Red-top tube or gel-barrier tube

Collection

Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping

Storage Instructions

Refrigerate.

Stability Requirements

Temperature

Period

Room temperature

7 days

Refrigerated

14 days

Frozen

60 days

Freeze/thaw cycles

Stable x1

Causes for Rejection

Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types

Test Details

Use

Anti-Ro (SS-A) antibodies occur in 40-50% of SLE, 60-75% of primary Sjogren's syndrome (PSS) and in a high proportion of secondary SS whether the associated disease is in SLE, RA, PSS, polydermato-myositis, or primary biliary cirrhosis, but is >90% of subacute cutaneous lupus and in vasculitis-associated SS.

Autoantibodies to SS-B/La antigen are detected by EIA in 70-90% of primary and about 50% of secondary Sjogren syndrome (SS) and as well as in 30% of SLE and 80% of subacute cutaneous lupus and a majority of infants with complete heart block.

Antibodies directed against alpha-fordin can be useful in diagnosing early stage Sjorgen's syndrome.

Limitations

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Enzyme-linked immunosorbent assay (ELISA)

Reference Interval

• Negative: <20

• Weak Positive: 20–39

• Moderate Positive: 40–80

• Positive: >80

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
520196 Sjogren's Profile Plus (RDL) Pending 520218 Anti-Ro (SS-A) Ab (RDL) Units 33569-5
520196 Sjogren's Profile Plus (RDL) Pending 520225 Anti-La (SS-B) Ab (RDL) Units 45142-7
520196 Sjogren's Profile Plus (RDL) Pending 520135 Anti-Fodrin Ab, IgG (RDL) Units 96928-7
520196 Sjogren's Profile Plus (RDL) Pending 520136 Anti-Fodrin Ab, IgA (RDL) Units 96918-8

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