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Test Includes
Anti-Ro (SS-A); Anti-La (SS-B); Anti-Fodrin Abs, IgG and IgA
Expected Turnaround Time
7 - 10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
2 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping
Storage Instructions
Refrigerate.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Test Details
Use
Anti-Ro (SS-A) antibodies occur in 40-50% of SLE, 60-75% of primary Sjogren's syndrome (PSS) and in a high proportion of secondary SS whether the associated disease is in SLE, RA, PSS, polydermato-myositis, or primary biliary cirrhosis, but is >90% of subacute cutaneous lupus and in vasculitis-associated SS.
Autoantibodies to SS-B/La antigen are detected by EIA in 70-90% of primary and about 50% of secondary Sjogren syndrome (SS) and as well as in 30% of SLE and 80% of subacute cutaneous lupus and a majority of infants with complete heart block.
Antibodies directed against alpha-fordin can be useful in diagnosing early stage Sjorgen's syndrome.
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Enzyme-linked immunosorbent assay (ELISA)
Reference Interval
• Negative: <20
• Weak Positive: 20–39
• Moderate Positive: 40–80
• Positive: >80
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520196 | Sjogren's Profile Plus (RDL) | Pending | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| 520196 | Sjogren's Profile Plus (RDL) | Pending | 520225 | Anti-La (SS-B) Ab (RDL) | Units | 45142-7 |
| 520196 | Sjogren's Profile Plus (RDL) | Pending | 520135 | Anti-Fodrin Ab, IgG (RDL) | Units | 96928-7 |
| 520196 | Sjogren's Profile Plus (RDL) | Pending | 520136 | Anti-Fodrin Ab, IgA (RDL) | Units | 96918-8 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf