Human Immunodeficiency Virus 1 (HIV-1) PhenoSense Integrase® (Monogram® Integrase Inhibitor Resistance)

TEST: 550230
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CPT: 87903
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Synonyms

  • PhenoSense Integrase®
  • Raltegravir

Expected Turnaround Time

19 - 23 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Information

Related Documents

For more information, please view the literature below.

HIV Specimen Collection Guide

HIV-1 Lifecycle, Drugs, and Susceptibility Assays

Supporting Individualized HIV Treatment Decisions

Specimen Requirements

Specimen

Plasma, frozen

Volume

3 mL

Container

Lavender-top (EDTA) or plasma preparation tube (PPT™).

Collection

Collect specimen in two lavender-top (EDTA) tubes or two PPT™ tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection. Transfer plasma to one or more polypropylene screw-capped tube(s) (not "pop-top" or "snap-cap") and freeze. Ship specimen frozen. To avoid delays in turnaround time, when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.

Storage Instructions

Freeze

Causes for Rejection

PPT™ not centrifuged; insufficient volume; heparinized plasma; nonfrozen specimens

Test Details

Use

The PhenoSense Integrase® assay is a phenotypic resistance test used to determine the susceptibility of a patient's HIV to integrase inhibitors. Integrase inhibitors block HIV replication by preventing the virus from integrating into the host cell's DNA. Raltegravir (Isentress®) is the first approved drug in this class of HIV antiretroviral drugs.

Limitations

This procedure should be used for patients with documented HIV-1 infection and viral loads ≥500 copies/mL.

Methodology

Polymerase chain reaction (PCR) amplification and viral culture. PhenoSense Integrase® is a trademark of Monogram Biosciences®.

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
550230 PhenoSense Integrase(R) 550238 PhenoSense Integrase(R) PDF 45182-3
550230 PhenoSense Integrase(R) 550239 PhenoSense Integrase(R) 61199-6
550230 PhenoSense Integrase(R) 550246 PhenoSense Integrase(R)Interp 77202-0

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