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Human Immunodeficiency Virus 1 (HIV-1) Trofile® (Monogram® Coreceptor Tropism)
CPT:
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Synonyms
- CCR5
- Chemokine Coreceptor Tropism Trofile®
- CXCR4
Expected Turnaround Time
27 - 35 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Plasma, frozen
Volume
3 mL
Container
Lavender-top (EDTA) or plasma preparation tube (PPT™)
Collection
Collect specimen in two lavender-top (EDTA) tubes or two PPT™ tubes. Do not use green-top (heparin) tubes. Centrifuge specimen within six hours of collection. Transfer plasma to one or more polypropylene screw-capped tube(s) (not "pop-top" or "snap-cap"), and freeze. Ship specimen frozen. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze
Causes for Rejection
PPT™ not centrifuged; insufficient volume; heparinized plasma; nonfrozen specimen
Test Details
Use
Detect HIV-1 coreceptor tropism; determine eligibility for CCR5 antagonist therapy such as maraviroc (Selzentry®)
Limitations
This procedure should be used for patients with documented HIV-1 infection and viral loads ≥1000 copies/mL.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Polymerase chain reaction (PCR) amplification and viral culture. Samples are forwarded to Monogram Biosciences® for testing, reporting, and billing. Trofile® is a trademark of Monogram Biosciences®.
References
Whitcomb JM, Huang W, Fransen S, et al. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob Agents Chemother. 2007; 51(2):566-575.17116663
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 553100 | Trofile(R) | 829632 | Trofile(R) PDF | 51969-4 | ||
| 553100 | Trofile(R) | 829666 | Tropotype: | 50790-5 | ||
| 553100 | Trofile(R) | 829633 | Trofile(R) | 57182-8 | ||
| 553100 | Trofile(R) | 829634 | Trofile(R) Interpretation | 77202-0 | ||
| 553100 | Trofile(R) | 829635 | Trofile(R) Methodology | 49549-9 | ||
| 553100 | Trofile(R) | 829636 | Trofile(R) References | 75608-0 |
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CPT Statement/Profile Statement
The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf