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Allergen Profile, Food, IgE With Component Reflexes
CPT:
86003(x16); 86008
Test Includes
This profile includes the nine major allergen groups associated with food allergy1-4 and their reflexes to components: almond; Brazil nut; cashew nut; codfish; egg white; hazelnut (filbert); milk; peanut (whole); salmon; scallop; sesame seed; shrimp; soybean; tuna; walnut; wheat and w5-gliadin (tri-19).
• If milk IgE ≥ 0.35 kU/L, reflex tests α-lactalbumin, β-lactoglobulin and casein will be added.
• If egg white IgE ≥ 0.35 kU/L, reflex tests ovalbumin and ovomucoid will be added.
• If sesame IgE ≥ 0.10 kU/L, reflex test Ses I 1 will be added.
• If walnut IgE ≥ 0.10 kU/L, reflex tests Jug r 1 and Jug r 3 will be added.
• If hazelnut (filbert) IgE ≥ 0.10 kU/L, reflex tests Cor a 1, Cor a 8, Cor a 9 and Cor a 14 will be added.
• If cashew nut IgE ≥ 0.10 kU/L, reflex test Ana o 3 will be added.
• If Brazil nut IgE ≥ 0.10 kU/L, reflex test Ber e 1 will be added.
• If peanut (whole) IgE ≥0.10 kU/L, reflex tests Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8 and Ara h 9 will be added.
• If wheat IgE ≥ 0.10 kU/L, one or more of the following components may be tested: Gliadin, Tri a 14 (wheat nsLTP), Phl p 12 (Timothy grass profilin) and/or Cross-reactive Carbohydrate Determinant (CCD).
Expected Turnaround Time
4 - 6 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
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4 - 6 days |
Related Information
- Allergen Profile, Brazil Nut, IgE With Component Reflexes
- Allergen Profile, Cashew Nut, IgE With Component Reflex
- Allergen Profile, Egg White, IgE With Component Reflexes
- Allergen Profile, Hazelnut, IgE With Component Reflexes
- Allergen Profile, Milk, IgE With Component Reflexes
- Allergen Profile, Peanut, IgE With Component Reflexes
- Allergen Profile, Sesame, IgE With Component Reflex
- Allergen Profile, Walnut, IgE With Component Reflex
Related Documents
Specimen Requirements
Specimen
Serum
Volume
4 mL
Minimum Volume
3 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 3 months |
| Freeze/thaw cycles | Stable x3 |
Test Details
Use
This panel is designed to measure the extent of allergen sensitization in children, adolescents and adults.
Methodology
Thermo Fisher ImmunoCAP® Allergen-specific IgE
Footnotes
1. Sicherer SH, Warren CM, Dant C, Gupta RS, Nadeau KC. Food Allergy from Infancy Through Adulthood. J Allergy Clin Immunol Pract. 2020 Jun;8(6):1854-1864.32499034
2. Major Allergens: The Big Nine. School Nutrition Association (SNA) website: https://schoolnutrition.org/resource/major-allergens-the-big-nine/. Accessed January 2024.
3. Food Allergies. U.S. Food and Drug Administration website: https://www.fda.gov/food/food-labeling-nutrition/food-allergies. Accessed January 2024.
4. Food Allergy & Anaphylaxis. Food Allergy and Anaphylaxis Connection Team website: https://www.foodallergyawareness.org/food-allergy-and-anaphylaxis/food-allergens/the-top-9-foodallergens/. Accessed January 2024.
References
Gupta RS, Warren CM, Smith BM, et al. Prevalence and Severite of Food Allergies Among US Adults. JAMA Netw Open. 2019 Jan 4;2(1):e185630.30646188
Gupta RS, Warren CM, Smith BM, et al. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018 Dec;142(6):e20181235.30455345
Savage J, Sicherer S, Wood R. The Natural History of Food Allergy. J Allergy Clin Immunol Pract. 2016 Mar-Apr;4(2):196-203; quiz 204.26968958
Sicherer SH, Sampson HA. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018 Jan;141(1):41-58.29157945
Sicherer SH, Sampson HA. Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014 Feb;133(2):291-307; quiz 308.24388012
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