February 18, 2025

Biodistribution Assessment of Lipid Nanoparticle-Mediated mRNA Delivery Using In Vivo Imaging

Cayman Chemical’s LNP development services in partnership with Labcorp utilizes in vivo imaging technology to create a comprehensive LNP screening platform. With this approach, three LNP formulations were assessed in vitro and in vivo for potency of reporter gene expression and differential organ delivery. This comprehensive LNP formulation, characterization, and analysis service can be used to identify candidate LNP formulations with tissue-tropic distribution.
March 4, 2025

Continuous infusion in minipigs via semi-permanent over-the-wire central venous catheters using OrchesTA infusion pumps

IAT Congress 2025 -- Our previous methods for intravenous dosing in minipigs were either placing short-term intravenous cannula into the peripheral (saphenous) vein, which is only suitable for bolus or short infusion, or a vascular access port (VAP), involving surgical cannulation of the femoral vein attached to a subcutaneous port on the trunk with a recovery period of 14 days before the port can be used. Following successful use of semi-permanent over-the-wire central venous catheters for repeat blood sampling in minipigs at Harrogate and Huntingdon, it was proposed to use the model for a 24-hour continuous infusion. This was a refinement from the VAP model, as the simpler procedure involved a much shorter anaesthesia and was possible to do within annex of the animal home area, removing the need for transport to the veterinary theatre. It also avoided the need for surgical placement of the catheter and subsequent recovery period with medication administration. The cannulas were well tolerated by the minipigs.
March 4, 2025

Test or enrichment?

IAT Congress 2025 -- Are behavioral tests just research tools, or could they be enriching for the rodents themselves? By observing their natural behaviors – like exploring, problem solving and social interactions – we not only model conditions such as anxiety, Alzheimer’s, schizophrenia and addiction, but also uncover how different drugs influence key neurotransmitters like dopamine, serotonin and acetylcholine. So, are these tests just science, or are they a form of enrichment too? Let’s explore!
March 4, 2025

Positive reinforcement training: Old-World NHPs

IAT Congress 2025 -- Positive reinforcement training (PRT) is increasingly used to refine scientific and husbandry procedures involving Old-World nonhuman primates (NHPs) around the globe. PRT provides mental stimulation as well as reduces stress for NHPs, which leads to better overall wellbeing and more accurate science. The understanding of behaviour as an indicator of welfare has gained enormous support in the past 20 years and our awareness to this allows us to continue improving our standards and processes.
March 4, 2025

Rabbit exercising program in a laboratory environment

IAT Congress 2025 -- New Zealand White rabbits are descended from the European rabbit, a social species that typically lives in large warrens. Both rabbits exhibit many of the same behaviors such as chewing, rearing, hiding and playing. Group exercising allows rabbits to express a broader range of natural behaviors that are not always available to individually housed rabbits.