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Synonyms
Preeclampsia, First Trimester
Special Instructions
For test inquiries, call CMBP genetic services at 800-345-4363. The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure (MAP), uterine artery pulsatility index (UtAPI is optional) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. The UtAPI measurement is optional but desired and if provided must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided.
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For test inquiries, call CMBP genetic services at 800-345-4363. The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure, uterine artery pulsatility index (UtAPI) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. NT can be assessed when the CRL is 45 to 84 mm. |
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For test inquiries, call CMBP genetic services at 800-345-4363. The following information must also be provided: patient's weight and height, patient's date of birth, four blood pressure measurements (two from each arm) or mean arterial pressure (MAP), uterine artery pulsatility index (UtAPI is optional) and number of fetuses. Also indicate relevant patient history (i.e., prior history of preeclampsia, diabetes, smoking status). Serum testing is provided from 11.0 to 14.0 weeks gestation. The UtAPI measurement is optional but desired and if provided must be performed by a sonographer credentialed by the Fetal Medicine Foundation or other equivalent entity. The sonographer's credential/certification number must be provided.
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Expected Turnaround Time
2 - 5 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Serum
Volume
3 mL
Minimum Volume
1 mL
Container
Gel-barrier tube
Collection
Collect in serum separator tube with gel barrier. Allow blood to clot, avoiding hemolysis. Separate serum from cells by centrifugation. Transport spun tube to testing laboratory frozen (preferred) or refrigerated.
Storage Instructions
Frozen (preferred) or refrigerated
Stability Requirements
| Temperature | Period |
|---|---|
| Room temperature | Unstable |
| Refrigerated | 10 days |
| Frozen | 10 days |
| Freeze/thaw cycles | Stable x3 |
Causes for Rejection
Gross hemolysis; gross lipemia; quantity not sufficient for analysis; improper specimen type; received at room temperature
Test Details
Use
This test is a screening test for the development of preeclampsia prior to 34 weeks of pregnancy.
Limitations
This is a screening test for preeclampsia to classify patients as low or high risk to develop preeclampsia later in pregnancy.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
Methodology
Fluoroimmunometric assay
References
Tan MY, Wright D, Syngelaki A, et al. Comparison of diagnostic accuracy of early screening for pre-eclampsia by NICE guidelines and a method combining maternal factors and biomarkers: results of SPREE. Ultrasound Obstet Gynecol. 2018 Jun;51(6):743-750. PubMed 29536574
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