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Antiphospholipid Syndrome (APS), Comprehensive (Esoterix)
CPT:
85597; 85598; 85613(x2); 85730; 85732(x2); 86146(x3); 86147(x3); 86148(x2); 86849
Test Includes
Activated partial thromboplastin time (aPTT); aPTT 1:1 NP; aPTT 1:1 saline; anticardiolipin antibody, IgA, IgG, IgM; antiphosphatidylserine, IgG, IgM; antiprothrombin antibody, IgG; β2-glycoprotein 1, IgA, IgG, IgM; dilute Russell's viper venom time (dRVVT) confirm seconds; dilute Russell's viper venom time (dRVVT) ratio; hexagonal phospholipid neutralization; lupus anticoagulant interpretation; platelet neutralization
Expected Turnaround Time
3 - 9 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Serum and plasma, frozen
Volume
Three 2 mL each frozen citrated plasma tubes and one 1 mL tube frozen serum
Container
Blue-top (sodium citrate) tubes and red-top tube or gel-barrier tube
Collection
Serum/plasma must be separated from cells within 45 minutes of venipuncture. Send serum/plasma in plastic transport tubes. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Freeze.
Causes for Rejection
Wrong sample type; fibrin clot in plasma sample
Test Details
Use
Determine the presence of antiphospholipid antibodies, using either clot-based or ELISA technology, that may be associated with an increased risk for arterial or venous thrombosis or obstetric complications. These antibodies may also be the cause of an elevated activated partial thromboplastin time (aPTT).
Methodology
See individual tests.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 504400 | Antiphospholipid Syndrome Comp | 500513 | APTT | sec | 14979-9 | |
| 504400 | Antiphospholipid Syndrome Comp | 500363 | APTT 1:1 NP | sec | 5946-9 | |
| 504400 | Antiphospholipid Syndrome Comp | 500364 | APTT 1:1 Saline | Sec | 43734-3 | |
| 504400 | Antiphospholipid Syndrome Comp | 501549 | DRVVT Screen Seconds | sec | 6303-2 | |
| 504400 | Antiphospholipid Syndrome Comp | 501548 | DRVVT Confirm Seconds | sec | 57838-5 | |
| 504400 | Antiphospholipid Syndrome Comp | 500585 | DRVVT Ratio | ratio | 50410-0 | |
| 504400 | Antiphospholipid Syndrome Comp | 500569 | Hexagonal Phospholipid Neutral | sec | 3282-1 | |
| 504400 | Antiphospholipid Syndrome Comp | 500049 | Platelet Neutralization | sec | 75506-6 | |
| 504400 | Antiphospholipid Syndrome Comp | 500575 | Anticardiolipin Ab, IgG | GPL | 3181-5 | |
| 504400 | Antiphospholipid Syndrome Comp | 500571 | Anticardiolipin Ab, IgM | MPL | 3182-3 | |
| 504400 | Antiphospholipid Syndrome Comp | 500581 | Anticardiolipin Ab, IgA | APL | 5076-5 | |
| 504400 | Antiphospholipid Syndrome Comp | 500589 | Beta-2 Glycoprotein I, IgG | SGU | 16135-6 | |
| 504400 | Antiphospholipid Syndrome Comp | 500593 | Beta-2 Glycoprotein I, IgM | SMU | 16136-4 | |
| 504400 | Antiphospholipid Syndrome Comp | 500591 | Beta-2 Glycoprotein I, IgA | SAU | 21108-6 | |
| 504400 | Antiphospholipid Syndrome Comp | 500577 | Antiphosphatidylserine IgG | GPS | 32032-5 | |
| 504400 | Antiphospholipid Syndrome Comp | 500579 | Antiphosphatidylserine IgM | MPS | 32033-3 | |
| 504400 | Antiphospholipid Syndrome Comp | 500782 | Antiprothrombin Antibody, IgG | G units | 40595-1 | |
| 504400 | Antiphospholipid Syndrome Comp | 502038 | LAC Interpretation | 77202-0 |
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