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Synonyms
- aCGH
- CGH
- CMA
- Microarray Oncology
- Reveal® SNP Array
- WGA
Special Instructions
Pertinent medical findings should accompany the test request form. If prior FISH analysis has been performed, include copy of report. Please direct questions to genetic customer service at 800-345-4363.
This assay currently is not available in New York state.
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Pertinent medical findings should accompany the test request form. If prior FISH analysis has been performed, include copy of report. Please direct questions to genetic customer service at 800-345-4363. <. |
|
Pertinent medical findings should accompany the test request form. If prior FISH analysis has been performed, include copy of report. Please direct questions to genetic customer service at 800-345-4363. This assay currently is not available in New York state. |
Expected Turnaround Time
12 - 15 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
Specimen Requirements
Specimen
Formalin fixed paraffin embedded (FFPE) tissue
Volume
One paraffin block or ten 10-micron thick section slides
Minimum Volume
Sufficient sample to obtain enough DNA to run microarray
Container
Paraffin block transport pouch
Collection
FFPE specimen should be fixed in 10% neutral-buffered formalin or formaldehyde.
Storage Instructions
Room temperature
Causes for Rejection
Improperly embedded preparation; decalcified bone or bone core
Test Details
Use
This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.
Limitations
This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy. Genotypes in some formalin-fixed tissues are unable to be determined, allowing only genomic dosage to be determined.
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
SNP Microarray analysis is performed using the Oncoscan® FFPE platform, which uses more than 220,000 SNP probes with a median spacing of 5.0 kb, within the majority of genes.
References
Nauen D, Haley L, Lin MT, et al. Molecular analysis of pediatric oligodendrogliomas highlights genetic differences with adult counterparts and other pediatric gliomas. Brain Pathol. 2016 Mar;26(2):206-214.26206478
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