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Analytical Performance of Contrived Samples for Validation of Liquid Biopsy Assays

April 7, 2024

Contrived samples, prepared from cell line derived DNA and cell line derived DNA spiked into non-cancerous cfDNA plasma to mimic the features of cfDNA, facilitates robust testing of rare variants in clinical samples and further supports analytical validation studies. This retrospective analysis of sensitivity studies demonstrated that contrived samples may be an appropriate substitute for clinical samples.