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Adoptive Cell & CAR T-Cell Therapies

With over 80 unique hematological malignancy cell lines, such as the CD19+ Raji-Luc lymphoma model, the MV-4-11-Luc-mCh-Puro leukemia model, and the MM.1S-Luc-Neo multiple myeloma model, we lead the industry with market-relevant models for your studies. También tenemos una creciente lista de modelos de tumores sólidos validados en ratones NSG para respaldar el impulso del campo hacia la aprobación de una terapia celular adoptiva (TCA) en una indicación de tumor sólido.

Discover an unparalleled breadth of experience in the use of mouse tumor models to evaluate ACTs.

With a broad range of disseminated and subcutaneous tumor models characterized in NSG mice, and a scientific team that knows how to apply them, we can guide selection of the right tumor model for your Chimeric Antigen Receptor (CAR) T-cell study or other ACT study.

Tumor Models by Histotype, Characterized in NSG Mice

 

HistotipoModelo
Acute monocytic leukemiaMV-4-11-Luc-mCh-Puro (disseminated)
THP1-Luc-mCh-Puro (disseminated)
Burkitt's lymphomaDaudi-Luc-mCh-Puro (disseminated)
Raji-Luc (SC/disseminated)
Leucemia linfoblásticaNALM6-Luc-mCh-Puro (SC/disseminated)
Leucemia mieloideKasumi-3-Luc-mCh-Puro (disseminated)
KG-1-Luc-mCh-Puro (disseminated)
Mieloma de células plasmáticasMM1.S-Luc-Neo (disseminated)
MOLM-13 (disseminated)
NCI-H929-Luc-mCh-Puro (disseminated)
RPMI-8226 (SC)
Promyelocytic leukemiaHL-60-Luc-mCh-Puro (disseminated)

 

 

HistotipoModelo
Bladder carcinomaSW780 (SC)
Breast/mammary carcinomaBT-474 (SC)
HCC70 (SC)
MDA-MB-231 (OT)
MDA-MB-231-Luc-D3H2LN
MDA-MB-468 (SC)
ZR-75-1 (SC)
Carcinoma gástricoNCI-N87 (SC)
SNU-5 (SC)
GlioblastomaU-251-Luc-mCh-Puro (SC/intracranial)
Carcinoma hepatocelularHep 3B2,1-7 (SC)
Hep G2 (SC)
Hypopharyngeal squamous cell carcinomaFaDu
Lung cancer: Non-small cell lung carcinomaA549 (SC)
Calu-3
NCI-H1299 (SC)
NCI-H1703 (SC)
NCI-H1975 (SC)
NCI-H1975-Luc (SC)
Lung cancer: Small cell lung carcinomaDMS-114 (SC)
NCI-H446 (SC)
NCI-H82 (SC)
SHP-77 (SC)
MelanomaA-375 (SC)
SK-MEL-28 (SC)
Ovarian carcinomaOV-90 (SC)
OVCAR-8-Luc-mCh-Puro (SC/IP)
PA-1 (SC)
SK-OV-3 (SC)
SK-OV-3-Luc-D3 (IP)
Pancreatic ductal adenocarcinomaBxPc-3 (SC)
MIA PaCa-2 (SC)
Carcinoma de próstata22Rv1 (SC)
LNCaP clone FGC (SC)
PC-3 (SC)
PC-3M-Luc-C6 (SC)

 

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