Combination of Rapamycin with Immune Checkpoint Blockade in a Syngeneic Breast Carcinoma Model

Use of image-guided focal irradiation is a mainstay of human cancer treatment. Image guidance allows for highly conformal treatment plans that minimize normal tissue toxicity and systemic response. With the advent of image-guided small animal irradiators such as the Small Animal Radiation Research Platform (SARRP; Xstrahl Inc., Suwanee, GA), targeted focal irradiation can now be utilized in a broad range of preclinical oncology models. Of particular interest is the possible use of focal irradiation to broaden the efficacy and response duration of immuno-oncology therapy. Here we identified base-line response of several syngeneic mouse models to focal irradiation therapy.