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Poster

Comprehensive genomic and immune profiling of ALK fusion-positive and negative lung adenocarcinomas

November 3, 2023

ALK-positive lung adenocarcinomas are associated with a younger age at sequencing, lower tumor mutational burden, higher PD-L1 expression, and lower cancer testis antigen burden compared to ALK-wild-type, EGFR mutated, and KRAS mutated lung adenocarcinomas. Our results suggest a need for considering patients with ALK-positive lung adenocarcinomas in clinical trials involving immune checkpoint inhibitors despite their exclusion in many trials.