BSTP 2024 -- Canine uveodermatologic syndrome (UDS) is an autoimmune disorder targeting tyrosinase or tyrosinase-related proteins within melanocytes and partially resembling human Vogt-Koyanagi-Harada syndrome. For the American Akita dog breed, a higher risk to develop UDS has related to the dog leukocyte antigen haplotype: (DLA)-DQAI*00201. The syndrome is usually observed at the mean age of 3.6 years, and female-to-male ratio is 0.6 to 1. UDS has not been reported as a spontaneous change in beagle laboratory dogs, although it has been reported as an experimentally induced change in animal models including rats, dogs and monkeys. 

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