Generation of polyclonal anti-idiotype antibodies

An idiotype is a unique antigen-binding site in an antibody and is made up of several epitopes in the variable region. Antibodies raised against the idiotype of a given antibody are called anti-idiotypic antibodies or commonly anti-Ids. These anti-Ids are highly specialized reagents that are produced against human monoclonal antibody (mAb) drug therapeutics. Anti-Id antibodies are generally used for the detection, identification and analysis of therapeutic drugs or as a positive control in immunogenicity assays to support preclinical and clinical development.