Investigating CAR-T cell efficacy and activation in the disseminated NALM-6-luc human B-cell acute lymphoblastic leukemia model

AACR 2024 -- Chimeric Antigen Receptor T (CAR-T) cell therapy has emerged as a promising approach for treating hematological malignancies, particularly B-cell acute lymphoblastic leukemia (B-ALL). This study aimed to delve into the activation dynamics and therapeutic efficacy of CD19 CAR-T cells in a disseminated NALM6-luc-mCh-Puro (NALM6-luc) human B-ALL murine model.