Optimization of Thawing Process for Analysis of Clinical Chemistry Analytes on Frozen Samples

AACC 2021 -- Clinical studies often involve collection and shipment of serum or plasma samples in frozen conditions from collection sites and multicenter laboratories, to central labs for analysis (Cuhadar et al., 2013). These samples are thawed to room temperature for analysis but often not mixed well before testing, which is an important pre-analytical step. Mixing samples after thawing is important to maintain the homogeneity of the samples and to obtain accurate results. The purpose of this study is to evaluate how mixing of the samples after thawing effects the results of common chemistry analytes.