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- PD-L1 Non-specific
Special Instructions
Note: This test number is used for tracking oncology IHC specimens to the laboratory. Bill codes will be added when testing is complete, based on the processes performed in the laboratory.
Expected Turnaround Time
1 - 2 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Specimen Requirements
Specimen
Formalin-fixed paraffin-embedded (FFPE) tissue block or slides
Volume
One tissue block or five unstained positively charged slides less than one month in age
Minimum Volume
At least three unstained slides sectioned at 4-5 microns
Container
Paraffin block or unstained positive charged slides
Collection
Paraffin block or unstained slides sectioned of no more than one month age.
Causes for Rejection
Slides sectioned greater than one month prior to test request
Test Details
Use
PD-L1 overexpression is associated with adverse prognosis in solid tumors, though specific prognosis varies among different tumor types. The utility of this PD-L1 (22C3) assay in predicting the response to therapy has not been determined for all tumor types, and standardized scoring methods do not exist for all tumor types.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
Immunohistochemistry
References
Wang Q, Liu F, Liu L. Prognostic significance of PD-L1 in solid tumor: an updated meta-analysis. Medicine (Baltimore). 2017 May;96(18):e6369.28471952
Wu P, Wu D, Li L, Chai Y, Huang J. PD-L1 and survival in solid tumors: a meta-analysis. PLoS One. 2015 Jun 26;10(6):e013140.26114883
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 452366 | PD-L1 Quantitative by IHC | 452367 | Referring Physician | 18781-5 | ||
| 452366 | PD-L1 Quantitative by IHC | 452368 | Treating Physician | 18781-5 | ||
| 452366 | PD-L1 Quantitative by IHC | 452369 | Client Specimen ID | 48767-8 | ||
| 452366 | PD-L1 Quantitative by IHC | 452370 | Contain(s) Received | 74384-9 | ||
| 452366 | PD-L1 Quantitative by IHC | 452371 | Clinical Data | 55752-0 | ||
| 452366 | PD-L1 Quantitative by IHC | 452372 | Revision Text | N/A | ||
| 452366 | PD-L1 Quantitative by IHC | 452373 | Body Site | 39111-0 | ||
| 452366 | PD-L1 Quantitative by IHC | 452374 | Specimen Type | 66746-9 | ||
| 452366 | PD-L1 Quantitative by IHC | 452375 | Interpretation | 50595-8 | ||
| 452366 | PD-L1 Quantitative by IHC | 452376 | Test(s) Cancelled | N/A | ||
| 452366 | PD-L1 Quantitative by IHC | 452378 | Comments: | 77202-0 | ||
| 452366 | PD-L1 Quantitative by IHC | 452379 | Reviewing Pathologist | 19139-5 | ||
| 452366 | PD-L1 Quantitative by IHC | 452380 | General Results | 19146-0 | ||
| 452366 | PD-L1 Quantitative by IHC | 452381 | Result | 55229-9 | ||
| 452366 | PD-L1 Quantitative by IHC | 452382 | Non Standard Comments | 8251-1 | ||
| 452366 | PD-L1 Quantitative by IHC | 452383 | Additional Notation | 48767-8 | ||
| 452366 | PD-L1 Quantitative by IHC | 452384 | Electronically Signed by | 19139-5 | ||
| 452366 | PD-L1 Quantitative by IHC | 452385 | Proxy Release by | 19139-5 | ||
| 452366 | PD-L1 Quantitative by IHC | 452386 | Disclaimer | 62364-5 | ||
| 452366 | PD-L1 Quantitative by IHC | 452387 | 11502-2 | |||
| 452366 | PD-L1 Quantitative by IHC | 452103 | Bill Code Entry Hold | N/A |
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