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- Prenatal Reveal®
- Reveal
- SNP
- SNP Microarray
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Special Instructions
A completed Informed Consent and Prenatal Chromosome SNP Microarray Questionnaire should accompany specimens. Call 800-345-4363 to request the Informed Consent and Questionnaire form. If a chromosome study has been performed, it is recommended that it be included with sample submission. If prior Cell-free DNA/NIPT studies have been performed, include a copy of the report.
Concurrent maternal contamination (MCC) Studies (Maternal Cell Contamination [511402]) are recommended. If direct amniotic fluid or chorionic villus samples (CVS) are submitted, test number will be changed to SNP Microarray (Direct)−Prenatal (Reveal®) [510200]. If direct submitted under Test No. 510200 doesn't meet requirements for microarray testing, test number will be changed to 510100 and cultures will be needed. Due to the nature of the culture process, an additional 2-3 weeks will be needed for culture growth before the sample can be shared for microarray testing. A delay notification will be sent to the client if cultures are necessary.
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A completed Informed Consent and Prenatal Chromosome SNP Microarray Questionnaire should accompany specimens. Call 800-345-4363 to request the Informed Consent and Questionnaire form. If a chromosome study has been performed, it If prior NIPT studies have been performed, include copy of the report. If specimens from a twin pregnancy are submitted by request, it can be reported if these are DZ or MZ twins. Concurrent maternal contamination (MCC) Studies (Maternal Cell Contamination [511402]) are recommended. If Direct Amniotic fluid or chorionic villus sample (CVS) submitted, test number will auto change to SNP Microarray (Direct)−Prenatal (Reveal®) [510200]. If Direct submitted under test number 510200 doesn't meet requirements for Microarray testing, test number will be changed to 510100 and cultures will be needed. If cultures are needed and performed by Labcorp, additional days will be required to complete testing. A delay notification will be sent to the client if cultures are necessary. |
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A completed Informed Consent and Prenatal Chromosome SNP Microarray Questionnaire should accompany specimens. Call 800-345-4363 to request the Informed Consent and Questionnaire form. If a chromosome study has been performed, it is recommended that it be included with sample submission. If prior Cell-free DNA/NIPT studies have been performed, include a copy of the report. Concurrent maternal contamination (MCC) Studies (Maternal Cell Contamination [511402]) are recommended. If direct amniotic fluid or chorionic villus samples (CVS) are submitted, test number will be changed to SNP Microarray (Direct)−Prenatal (Reveal®) [510200]. If direct submitted under Test No. 510200 doesn't meet requirements for microarray testing, test number will be changed to 510100 and cultures will be needed. Due to the nature of the culture process, an additional 2-3 weeks will be needed for culture growth before the sample can be shared for microarray testing. A delay notification will be sent to the client if cultures are necessary. |
Expected Turnaround Time
10 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
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10 - 21 days |
Related Information
Related Documents
For more information, please view the literature below.
SNP Microarray Prenatal POC Clinical Questionnaire
Reveal® SNP Microarray: Eligibility (Preverification) & Prior Authorization Request Form
Reveal® SNP Microarray: Revealing Answers to Complex Questions
Specimen Requirements
Specimen
Cultured amniotic fluid sample or chorionic villus sample (CVS) cells. Maternal cell contamination studies are recommended; submit maternal blood (EDTA) using Maternal Cell Contamination [511402].
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Cultured amniotic fluid sample or |
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Cultured amniotic fluid sample or chorionic villus sample (CVS) cells. Maternal cell contamination studies are recommended; submit maternal blood (EDTA) using Maternal Cell Contamination [511402]. |
Volume
Two T-25 flasks of cultured cells
Minimum Volume
One T-25 flask
Container
T-25 flask
Storage Instructions
Maintain specimen at room temperature.
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Maintain specimen at room temperature |
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Maintain specimen at room temperature. |
Causes for Rejection
Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory.
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Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory. |
Test Details
Use
This test will detect chromosomal imbalances that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent.
Limitations
This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only contain heterochromatin or tetraploidy.
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.
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SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses 743, |
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SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb. |
References
Coppinger J, Alliman S, Lamb A, et al. Whole-genome microarray analysis in prenatal specimens identifies clinically significant chromosome alterations without increase in results of unclear significance compared to targeted microarray. Prenatal Diagn. 2009 Dec; 29(12):1156-1166.19795450
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