Maternal Cell Contamination

TEST: 511402
Test number copied
CPT: 81265
Print Share

Special Instructions

Maternal samples sent for maternal cell contamination studies should be submitted under a separate requisition from fetal specimens (CVS or amniotic fluid).

Expected Turnaround Time

11 - 21 days

Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.

Related Documents

Specimen Requirements

Specimen

Whole blood or PurFlock buccal swab kit or Oragene Dx saliva kit

Volume

8.5 mL whole blood or PurFlock buccal swab kit or Oragene Dx 500 saliva collection kit

Minimum Volume

3 mL whole blood or PurFlock buccal swab kit or Oragene Dx saliva kit

Container

Lavender-top (EDTA) tube, pink-top (EDTA) tube, tan-top (EDTA) tube, yellow-top (ACD-A) tube, or PurFlock buccal swab kit or Oragene Dx 500 saliva collection kit

Storage Instructions

Standard phlebotomy. Follow PurFlock buccal swab kit or Oragene Dx 500 saliva kit collection instructions. Do not eat, drink, smoke or chew gum 30 minutes prior to collection.

Stability Requirements

Temperature

Period

Room temperature

Whole blood: 14 days; Buccal: 60 days; Saliva: 60 days

Refrigerated

Whole blood: 30 days at 4°C

Causes for Rejection

Frozen or hemolyzed specimen; quantity not sufficient for analysis; improper container

Test Details

Use

This test is used to rule out the presence of maternal cell contamination within a fetal specimen to aid in the accurate interpretation of prenatal molecular genetic or cytogenetic results.

Limitations

False positive or negative results may occur for reasons that include genetic variants, blood transfusions, bone marrow transplantation, or erroneous characterization of family relationships. Molecular-based testing is highly accurate, but as in any laboratory test, rare diagnostic errors may occur. Results are provided for identification of maternal cell contamination in the specimen itself, and not for diagnostic purposes.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Analysis of short tandem repeat markers by multiplex fluorescent polymerase chain reaction (PCR) and capillary electrophoresis

References

Bacher J, Schumm JM. Development of Highly Polymorphic Pentanucleotide Tandem Repeat Loci with Low Stutter. Promega Corporation Profiles in DNA. 1998;2(2):3-6.
Ensenberger M, Thompson J, Hill B, et al. Developmental validation of the PowerPlex 16 HS System: an improved 16-locus fluorescent STR multiplex. Forensic Sci Int Genet. 2010 Jul;4(4):257-264.20457027
Nagan N, Faulkner NE, Curtis C, Schrijver I, MCC Guidelines Working Group of the Association for Molecular Pathology Clininical Practice Committee. Laboratory guidelines for detection, interpretation, and reporting of maternal cell contamination in prenatal analyses a report of the association for molecular pathology. J Mol Diagn. 2011 Jan;13(1):7-11.21227389

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
511402 Maternal Cell Contamination 511401 Maternal Cell Contamination 59266-7
511402 Maternal Cell Contamination 511887 Specimen Type 31208-2
511402 Maternal Cell Contamination 511888 Result 41103-3
511402 Maternal Cell Contamination 511889 Director Review 72486-4
511402 Maternal Cell Contamination 512123 PDF 51967-8

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf