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CPT:
86038; 86147(x3); 86160(x2); 86225; 86235(x6); 86376
Synonyms
- ANA 12
- ANA 12 Panel
Test Includes
This profile is comprised of Anti‐Nuclear Ab (ANA) by IFA, Anti‐dsDNA Ab by Farr, Anti‐ENA Abs (Anti‐Sm & Anti‐RNP), Anti‐Centromere Ab, C3 & C4 Complements, Anti‐Ro (SS‐A) Ab, Anti‐La (SS‐B) Ab, Anti‐Scl‐70 Ab, Anti‐cardiolipin Abs (IgG, IgA & IgM isotypes), Anti‐TPO (Thyroid Microsomal Peroxidase) Ab, Anti‐Chromatin Ab.
Expected Turnaround Time
14 - 21 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Antinuclear Antibodies Testing Options in Rheumatology Brochure
Specimen Requirements
Specimen
Serum
Volume
4 mL
Minimum Volume
1.5 mL (Note: This volume does not allow for repeat testing.)
Container
Red-top tube or gel-barrier tube
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping. To avoid delays in turnaround time when requesting multiple tests on frozen samples, please submit separate frozen specimens for each test requested.
Storage Instructions
Refrigerate or freeze.
Stability Requirements
Temperature | Period |
|---|---|
Room temperature | 7 days |
Refrigerated | 14 days |
Frozen | 60 days |
Freeze/thaw cycles | Stable x1 |
Causes for Rejection
Grossly hemolyzed; bacterial contamination; lipemic specimen; icteric specimen; non-serum specimen types
Test Details
Use
The ANA test detects autoantibodies that bind to the nuclear components of HEp-2 cells. A positive ANA titer is not specific, but indicates the presence of one or more autoantibodies. Profiles of specific autoantibodies have diagnostic and potential prognostic utility for several autoimmune diseases.
RDL’s ANA 12 Profile Helps Differentiate Between 8 Autoimmune Disease States:
SLE
• ANA by IFA
Tests with high specificity
• Anti-dsDNA by Farr
• Anti-SM
Tests with moderate specificity
• Anti-Ro
• Anti-La
• C3 & C4 Complements
• Anticardiolipin IgG, IgA & IgM
Sjogren’s Syndrome
• Anti-Ro
• Anti-La
Mixed Connective Tissue Disease (MCTD)
• Anti-U1 RNP
Limited Scleroderma (CREST)
• Anti-Centromere
Diffuse Scleroderma
• Anti-SCL-70 by EIA, confirmed by ID
Autoimmune Thyroid Disease
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
See individual test components.
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520299 | ANA 12 Profile, Do All RDL | 520073 | Anti-Nuclear Ab by IFA (RDL) | 42254-3 | ||
| 520299 | ANA 12 Profile, Do All RDL | 520066 | Anti-Centromere Ab by IFA(RDL) | 5077-3 | ||
| 520299 | ANA 12 Profile, Do All RDL | 520060 | Anti-dsDNA Ab by Farr(RDL) | IU/mL | 47299-3 | |
| 520299 | ANA 12 Profile, Do All RDL | 520216 | Anti-Sm Ab (RDL) | Units | 11090-8 | |
| 520299 | ANA 12 Profile, Do All RDL | 520217 | Anti-U1 RNP Ab (RDL) | Units | 57662-9 | |
| 520299 | ANA 12 Profile, Do All RDL | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 | |
| 520299 | ANA 12 Profile, Do All RDL | 520225 | Anti-La (SS-B) Ab (RDL) | Units | 45142-7 | |
| 520299 | ANA 12 Profile, Do All RDL | 520221 | Anti-Scl-70 Ab (RDL) | Units | 26975-3 | |
| 520299 | ANA 12 Profile, Do All RDL | 520223 | Anti-Cardiolipin Ab, IgG (RDL) | GPL U/mL | 3181-5 | |
| 520299 | ANA 12 Profile, Do All RDL | 520182 | Anti-Cardiolipin Ab, IgA (RDL) | APL U/mL | 5076-5 | |
| 520299 | ANA 12 Profile, Do All RDL | 520183 | Anti-Cardiolipin Ab, IgM (RDL) | MPL U/mL | 3182-3 | |
| 520299 | ANA 12 Profile, Do All RDL | 520169 | C3 Complement (RDL) | mg/dL | 4485-9 | |
| 520299 | ANA 12 Profile, Do All RDL | 520167 | C4 Complement (RDL) | mg/dL | 4498-2 | |
| 520299 | ANA 12 Profile, Do All RDL | 520036 | Anti-TPO Ab (RDL) | IU/mL | 8099-4 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520074 | Homogeneous Pattern | 20398-4 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520076 | Nucleolar Pattern | 20399-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520233 | Speckled Pattern | 20401-6 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520234 | Centromere Pattern | 53993-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520235 | Spindle Apparatus Pattern | 53003-0 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520236 | Nuclear Membrane Pattern | 54006-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520237 | Midbody Pattern | 54155-7 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520238 | Nuclear Dot Pattern | 53998-1 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520239 | PCNA Pattern | 53006-3 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520240 | Centriole Pattern | 53993-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520077 | ANA Titer and Pattern | 520241 | Note: | 77202-0 | |
| Reflex Table for Anti-Scl-70 Ab (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520341 | Repeat Anti-Scl-70 | 520341 | Repeat Anti-Scl-70 | 5348-8 | |
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