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- Autoimmune (ANA) Rheumatic Disease
Special Instructions
Antinuclear Antibodies (ANA) by IFA testing is performed.
1) If ANA is positive, the following tests are performed: Anti-DsDNA (double-stranded) Ab by Farr (Radioimmunoassay), Anti-Sm, Complement C3, Complement C4, Anti-U1 RNP, Anti-Ro (SS-A), Anti-La (SS-B), Anti-Chromatin, Anti-Centromere, Anti-Scl70, Anti-Jo1, Anti-Cardiolipin Abs, IgG and IgM, and Anti-Beta 2 Glycoprotein I Abs, IgG and IgM.
2) If ANA by IFA is negative, RheumAssure (Rheumatoid Factor by Turbidimetry, Anti-CCP (Cyclic Citrullinated Peptide) Abs, IgG and IgA, and 14-3-3-eta is performed.
3) If 14-3-3-eta is negative, the Anti-TPO (Thyroperoxidase) Ab and Anti-Thyroglobulin Ab are performed.
Expected Turnaround Time
10 days
Turnaround time is defined as the usual number of days from the date of pickup of a specimen for testing to when the result is released to the ordering provider. In some cases, additional time should be allowed for additional confirmatory or additional reflex tests. Testing schedules may vary.
Related Documents
For more information, please view the literature below.
Specimen Requirements
Specimen
Serum
Volume
5 mL
Minimum Volume
4 mL
Container
2 red-top or gel-barrier tubes; transfer tubes
Collection
Separate serum from cells within one hour of collection. Transfer to a plastic transport tube before shipping.
Storage Instructions
Refrigerate.
Stability Requirements
Temperature | Period |
|---|---|
Refrigerated | 14 days |
Test Details
Use
This profile may be useful in diagnosing connective tissue or systemic autoimmune rheumatic disease.
Methodology
ELISA, RIA, IFA, Turbidity, ICMS
LOINC® Map
| Order Code | Order Code Name | Order Loinc | Result Code | Result Code Name | UofM | Result LOINC |
|---|---|---|---|---|---|---|
| 520340 | CTD Cascade | 520073 | Anti-Nuclear Ab by IFA (RDL) | 42254-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520074 | Homogeneous Pattern | 20398-4 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520076 | Nucleolar Pattern | 20399-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520233 | Speckled Pattern | 20401-6 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520234 | Centromere Pattern | 53993-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520235 | Spindle Apparatus Pattern | 53003-0 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520236 | Nuclear Membrane Pattern | 54006-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520237 | Midbody Pattern | 54155-7 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520238 | Nuclear Dot Pattern | 53998-1 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520239 | PCNA Pattern | 53006-3 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520240 | Centriole Pattern | 53993-2 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520241 | Note: | 77202-0 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520066 | Anti-Centromere Ab by IFA(RDL) | 5077-3 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520060 | Anti-dsDNA Ab by Farr(RDL) | IU/mL | 47299-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520169 | C3 Complement (RDL) | mg/dL | 4485-9 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520167 | C4 Complement (RDL) | mg/dL | 4498-2 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520218 | Anti-Ro (SS-A) Ab (RDL) | Units | 33569-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520225 | Anti-La (SS-B) Ab (RDL) | Units | 45142-7 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520216 | Anti-Sm Ab (RDL) | Units | 11090-8 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520217 | Anti-U1 RNP Ab (RDL) | Units | 57662-9 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520224 | Anti-Chromatin Ab, IgG (RDL) | Units | 32580-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520221 | Anti-Scl-70 Ab (RDL) | Units | 26975-3 |
| Reflex 2 | 520341 | Repeat Anti-Scl-70 | 520341 | Repeat Anti-Scl-70 | 5348-8 | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520259 | Anti-Jo-1 Ab (RDL) | Units | 35333-4 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520338 | Interpretation | Pending | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520223 | Anti-Cardiolipin Ab, IgG (RDL) | GPL U/mL | 3181-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520183 | Anti-Cardiolipin Ab, IgM (RDL) | MPL U/mL | 3182-3 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520355 | See below: | N/A | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520346 | Anti-Beta2 Glycoprotein I IgG | SGU | 21108-6 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520347 | Anti-Beta2 Glycoprotein I IgM | SMU | 16136-4 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520557 | See below: | N/A | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520336 | ANA POS Reflex | 520357 | See below: | N/A | |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520337 | ANA Neg Reflex | 520132 | Rheumatoid Factor by Turb RDL | IU/mL | 11572-5 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520337 | ANA Neg Reflex | 520047 | Anti-CCP Ab, IgG + IgA (RDL) | Units | 57093-7 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520337 | ANA Neg Reflex | 520206 | 14.3.3 ETA, Rheum. Arthritis | ng/mL | 75880-5 |
| Reflex 2 | 520354 | Thyroid Antibodies | 520036 | Anti-TPO Ab (RDL) | IU/mL | 8099-4 |
| Reflex Table for Anti-Nuclear Ab by IFA (RDL) | ||||||
|---|---|---|---|---|---|---|
| Order Code | Order Name | Result Code | Result Name | UofM | Result LOINC | |
| Reflex 1 | 520337 | ANA Neg Reflex | 520206 | 14.3.3 ETA, Rheum. Arthritis | ng/mL | 75880-5 |
| Reflex 2 | 520354 | Thyroid Antibodies | 520331 | Anti-Thyroglobulin Ab | IU/mL | Pending |
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