WagnerAACC19.pdf

AACC 2019 -- Symmetric and asymmetric dimethylarginine (SDMA and ADMA) are metabolites of the post-translational modification of arginine residues in histones. SDMA is produced by all body tissues and is cleared almost exclusively by the kidneys, making it an attractive biomarker for the evaluation of renal function. In this study, the development of an LC-MS/MS method for the measurement of SDMA is described and its performance reviewed against traditional renal markers in individuals with microalbuminuria or abnormal thyroid function.