Legionella pneumophila Urinary Antigen

CPT: 87449
Print Share

Expected Turnaround Time

1 - 3 days



Related Documents


Specimen Requirements


Specimen

Urine


Volume

5 mL


Container

Sterile screw-cap container


Storage Instructions

Refrigerate.


Causes for Rejection

Swab specimen; inappropriate specimen transport device; unlabeled specimen or name discrepancy between specimen and request label; nonurine specimen


Test Details


Use

Confirm the diagnosis of Legionella pneumophila serogroup 1 infection


Limitations

This test will not detect species or serogroups other than Legionella pneumophila serogroup 1.


Methodology

Enzyme immunoassay (EIA)


Reference Interval

No Legionella pneumophila serogroup 1 antigen detected


Additional Information

Legionella pneumophila has been estimated to cause 80% to 85% of Legionella infections, with serogroup 1 accounting for most of these. Current methods of diagnosis for Legionella infection include culture and DFA. All of these other tests require a high quality respiratory specimen to perform this test and, unfortunately, many patients with Legionella infection do not produce sputum. A number of investigators have shown that a specific soluble antigen was present in the urine of patients with Legionnaires' disease, which can be detected both early and late in the disease.


References

Berdal PP, Farshy CE, Feelley JC. Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay. J Clin Microbiol. 1979 May; 9(5):575-578. 383744
Kohler RB, Zimmerman SE, Wilson E, et al. Rapid immunoassay diagnosis of Legionnaires' disease: Detection and partial characterization of urinary antigen. Ann Intern Med. 1981 May; 94(5):601-605. 7235392
Reingold AL, Thomason BM, Brake BJ, Thacker L, Wilkinson HW, Kuritsky JN. Legionella pneumonia in the United States: The distribution of serogroups and species causing human illness. J Infect Dis. 1984 May; 149(5):819. 6726009

LOINC® Map

Order Code Order Code Name Order Loinc Result Code Result Code Name UofM Result LOINC
182246 L. pneumophila Serogp 1 Ur Ag 41499-5 182246 L. pneumophila Serogp 1 Ur Ag 41499-5

For Providers

Please login to order a test

Order a Test

© 2021 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.

CPT Statement/Profile Statement

The LOINC® codes are copyright © 1994-2021, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf